Ontology highlight
ABSTRACT:
SUBMITTER: Yamana S
PROVIDER: S-EPMC4404054 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yamana Shota S Tokiyama Amina A Mizutani Kiyohito K Hirata Ken-ichi K Takai Yoshimi Y Rikitake Yoshiyuki Y
PloS one 20150420 4
Contact inhibition of cell movement and proliferation is critical for proper organogenesis and tissue remodeling. We show here a novel regulatory mechanism for this contact inhibition using cultured vascular endothelial cells. When the cells were confluently cultured, Necl-4 was up-regulated and localized at cell-cell contact sites where it cis-interacted with the vascular endothelial growth factor (VEGF) receptor. This interaction inhibited the tyrosine-phosphorylation of the VEGF receptor thro ...[more]