Ontology highlight
ABSTRACT:
SUBMITTER: Schramm EC
PROVIDER: S-EPMC4404182 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Schramm Elizabeth C EC Staten Nick R NR Zhang Zhouning Z Bruce Samuel S SS Kellner Christopher C Atkinson John P JP Kyttaris Vasileios C VC Tsokos George C GC Petri Michelle M Sander Connolly E E Olson Paul K PK
Analytical biochemistry 20150204
Complement is a major effector arm of the innate immune system that responds rapidly to pathogens or altered self. The central protein of the system, C3, participates in an amplification loop that can lead to rapid complement deposition on a target and, if excessive, can result in host tissue damage. Currently, complement activation is routinely monitored by assessing total C3 levels, which is an indirect and relatively insensitive method. An alternative approach would be to measure downstream C ...[more]