Pre-transplant plasma Torque Teno virus load and increase dynamics after lung transplantation.

ABSTRACT:

Background

The human Torque Teno virus (TTV) causes persistent viremia in most immunocompetent individuals. Elevated TTV levels are observed after solid organ transplantation and are related to the extent of immunosuppression especially during the phase of maintenance immunosuppression. However, the extent to which the TTV increase in the early phase post-transplantation is associated with the patient's immunosuppressive state is unclear.

Objectives

In this study, we assessed the TTV increase dynamics in detail during the first three months after lung transplantation under a defined immunosuppressive regimen and in relation to the pre-transplant TTV level.

Study design

Forty-six lung transplant recipients (LTRs) were included in this prospective longitudinal study. Al

SUBMITTER: Gorzer I 

PROVIDER: S-EPMC4404260 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature