Ontology highlight
ABSTRACT:
SUBMITTER: Yuan A
PROVIDER: S-EPMC4405145 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Yuan Ahu A Laing Brian B Hu Yiqiao Y Ming Xin X
Chemical communications (Cambridge, England) 20150401 30
Activation of photosensitizers in endosomes enables release of therapeutic macromolecules into the cytosol of the target cells for pharmacological actions. In this study, we demonstrate that direct conjugation of photosensitizers to oligonucleotides (ONs) allows spatial and temporal co-localization of the two modalities in the target cells, and thus leads to superior functional delivery of ONs. Further, light-activated delivery of an anticancer ON caused cancer cell killing via modulation of an ...[more]