Ontology highlight
ABSTRACT:
SUBMITTER: Martin V
PROVIDER: S-EPMC440599 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Martin Valentina V Supanitsky Alicia A Echeverria Pablo C PC Litwin Silvana S Tanos Tamara T De Roodt Adolfo R AR Guarnera Eduardo A EA Angel Sergio O SO
Clinical and diagnostic laboratory immunology 20040701 4
The efficacy of vaccination with Toxoplasma gondii recombinant GRA4 (rGRA4) and ROP2 (rRPO2) proteins and a mix of both combined with alum were evaluated in C57BL/6 and C3H mice. In C57BL/6 mice, rGRA4 and rGRA4-rROP2 immunizations generated similar levels of immunoglobulin G1 (IgG1) and IgG2a isotypes against GRA4, whereas immunizations with rROP2 and the mix induced a predominant IgG1 production against ROP2. All groups of C3H vaccinated mice exhibited higher levels of IgG1 than IgG2a. rGRA4-s ...[more]