Ontology highlight
ABSTRACT:
SUBMITTER: Sheen CR
PROVIDER: S-EPMC4406354 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Sheen Campbell R CR Kuss Pia P Narisawa Sonoko S Yadav Manisha C MC Nigro Jessica J Wang Wei W Chhea T Nicole TN Sergienko Eduard A EA Kapoor Kapil K Jackson Michael R MR Hoylaerts Marc F MF Pinkerton Anthony B AB O'Neill W Charles WC Millán José Luis JL
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20150501 5
Medial vascular calcification (MVC) is a pathological phenomenon that causes vascular stiffening and can lead to heart failure; it is common to a variety of conditions, including aging, chronic kidney disease, diabetes, obesity, and a variety of rare genetic diseases. These conditions share the common feature of tissue-nonspecific alkaline phosphatase (TNAP) upregulation in the vasculature. To evaluate the role of TNAP in MVC, we developed a mouse model that overexpresses human TNAP in vascular ...[more]