Treatment of early-stage HER2+ breast cancer-an evolving field.
Ontology highlight
ABSTRACT:
SUBMITTER: Ferreira AR
PROVIDER: S-EPMC4406526 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Treatment of early-stage HER2+ breast cancer-an evolving field.
Ferreira Arlindo R AR Saini Kamal S KS Metzger-Filho Otto O
Ecancermedicalscience 20150416
The evolving field of HER2-targeted therapy has significantly improved the outcome of women diagnosed with HER2-positive invasive breast cancer. In this review, we sought to summarise the efficacy of trastuzumab-based regimens in the adjuvant and neoadjuvant setting with a special emphasis on relevant clinical questions: treatment duration, sequence of trastuzumab administration, toxicity, the role of anthracycline-based regimens, and optimal management of small HER2+ tumours. Controversial topi ...[more]
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