Ontology highlight
ABSTRACT:
SUBMITTER: Horvath S
PROVIDER: S-EPMC4406678 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Horvath Steve S Garagnani Paolo P Bacalini Maria Giulia MG Pirazzini Chiara C Salvioli Stefano S Gentilini Davide D Di Blasio Anna Maria AM Giuliani Cristina C Tung Spencer S Vinters Harry V HV Franceschi Claudio C
Aging cell 20150209 3
Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7 ...[more]