Ontology highlight
ABSTRACT:
SUBMITTER: Shih YH
PROVIDER: S-EPMC4406804 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Shih Yu-Huan YH Zhang Yuji Y Ding Yonghe Y Ross Christian A CA Li Hu H Olson Timothy M TM Xu Xiaolei X
Circulation. Cardiovascular genetics 20150111 2
<h4>Background</h4>Genetic studies of cardiomyopathy and heart failure have limited throughput in mammalian models. Adult zebrafish have been recently pursued as a vertebrate model with higher throughput, but genetic conservation must be tested.<h4>Methods and results</h4>We conducted transcriptome analysis of zebrafish heart and searched for fish homologues of 51 known human dilated cardiomyopathy-associated genes. We also identified genes with high cardiac expression and genes with differentia ...[more]