Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi Y
PROVIDER: S-EPMC4406844 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Takahashi Yusuke Y Chen Qian Q Rajala Raju V S RVS Ma Jian-Xing JX
FEBS letters 20150318 10
Aberrant activation of Wnt signaling contributes to ischemia-induced retinal neovascularization in oxygen-induced retinopathy (OIR), although the underlying mechanism is so far unclear. Here, we show that microRNA-184 (miR-184) is significantly down-regulated in the retina of OIR mice, and miR-184 negatively modulates Wnt signaling both in vivo and in vitro. Furthermore, we show that the Wnt receptor, frizzled-7, is a downstream target of miR-184, and delivery of miR-184 mimic inhibits Wnt signa ...[more]