Ontology highlight
ABSTRACT:
SUBMITTER: Laurette P
PROVIDER: S-EPMC4407272 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Laurette Patrick P Strub Thomas T Koludrovic Dana D Keime Céline C Le Gras Stéphanie S Seberg Hannah H Van Otterloo Eric E Imrichova Hana H Siddaway Robert R Aerts Stein S Cornell Robert A RA Mengus Gabrielle G Davidson Irwin I
eLife 20150324
Microphthalmia-associated transcription factor (MITF) is the master regulator of the melanocyte lineage. To understand how MITF regulates transcription, we used tandem affinity purification and mass spectrometry to define a comprehensive MITF interactome identifying novel cofactors involved in transcription, DNA replication and repair, and chromatin organisation. We show that MITF interacts with a PBAF chromatin remodelling complex comprising BRG1 and CHD7. BRG1 is essential for melanoma cell pr ...[more]