Ontology highlight
ABSTRACT:
SUBMITTER: Lammer AD
PROVIDER: S-EPMC4407279 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Lammer Aaron D AD Cook Melissa E ME Sessler Jonathan L JL
Journal of porphyrins and phthalocyanines 20150101 1-03
Gold(III) compounds continue to be explored for their potential utility as anticancer agents. A recognized limitation is the reactivity of gold(III), which is typically reduced to the more labile gold(I) state under physiological conditions. The use of porphyrins can overcome this problem. However, to date the stabilization provided by the use a strongly chelating porphyrin is offset by the poor solubility of the resulting complex in aqueous media. In this work, we describe the synthesis and <i> ...[more]