Unknown

Dataset Information

0

A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway.


ABSTRACT: Cell migration and invasion are key processes in the metastasis of cancer, and suppression of these steps is a promising strategy for cancer therapeutics. The aim of this study was to explore small molecules for treating colorectal cancer (CRC) and to investigate their anti-metastatic mechanisms. In this study, six CRC cell lines were used. We showed that YH-306 significantly inhibited the migration and invasion of CRC cells in a dose-dependent manner. In addition, YH-306 inhibited cell adhesion and protrusion formation of HCT116 and HT-29 CRC cells. Moreover, YH-306 potently suppressed uninhibited proliferation in all six CRC cell lines tested and induced cell apoptosis in four cell lines. Furthermore, YH-306 inhibited CRC colonization in vitro and suppressed CRC growth in a xenograft mouse model, as well as hepatic/pulmonary metastasis in vivo. YH-306 suppressed the activation of focal adhesion kinase (FAK), c-Src, paxillin, and phosphatidylinositol 3-kinases (PI3K), Rac1 and the expression of matrix metalloproteases (MMP) 2 and MMP9. Meanwhile, YH-306 also inhibited actin-related protein (Arp2/3) complex-mediated actin polymerization. Taken together, YH-306 is a candidate drug in preventing growth and metastasis of CRC by modulating FAK signalling pathway.

SUBMITTER: Dai F 

PROVIDER: S-EPMC4407606 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway.

Dai Fujun F   Chen Yihua Y   Huang Li L   Wang Jinhua J   Zhang Tao T   Li Jingjie J   Tong Weiguang W   Liu Mingyao M   Yi Zhengfang Z  

Journal of cellular and molecular medicine 20141029 2


Cell migration and invasion are key processes in the metastasis of cancer, and suppression of these steps is a promising strategy for cancer therapeutics. The aim of this study was to explore small molecules for treating colorectal cancer (CRC) and to investigate their anti-metastatic mechanisms. In this study, six CRC cell lines were used. We showed that YH-306 significantly inhibited the migration and invasion of CRC cells in a dose-dependent manner. In addition, YH-306 inhibited cell adhesion  ...[more]

Similar Datasets

| S-EPMC3736531 | biostudies-literature
| S-EPMC5129822 | biostudies-literature
| S-EPMC9025482 | biostudies-literature
| S-EPMC3376857 | biostudies-other
| S-EPMC7957922 | biostudies-literature
| S-EPMC4837478 | biostudies-literature
2022-05-20 | PXD031082 | Pride
| S-EPMC8908661 | biostudies-literature
| S-EPMC3531399 | biostudies-literature
| S-EPMC2684913 | biostudies-other