Ontology highlight
ABSTRACT:
SUBMITTER: Dai F
PROVIDER: S-EPMC4407606 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Dai Fujun F Chen Yihua Y Huang Li L Wang Jinhua J Zhang Tao T Li Jingjie J Tong Weiguang W Liu Mingyao M Yi Zhengfang Z
Journal of cellular and molecular medicine 20141029 2
Cell migration and invasion are key processes in the metastasis of cancer, and suppression of these steps is a promising strategy for cancer therapeutics. The aim of this study was to explore small molecules for treating colorectal cancer (CRC) and to investigate their anti-metastatic mechanisms. In this study, six CRC cell lines were used. We showed that YH-306 significantly inhibited the migration and invasion of CRC cells in a dose-dependent manner. In addition, YH-306 inhibited cell adhesion ...[more]