Ontology highlight
ABSTRACT:
SUBMITTER: Ali Khajeh J
PROVIDER: S-EPMC4407695 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Ali Khajeh Jahan J Ju Jeong Ho JH Atchiba Moussoubaou M Allaire Marc M Stanley Christopher C Heller William T WT Callaway David J E DJ Bu Zimei Z
Journal of molecular biology 20140529 15
The tumor suppressor protein Merlin inhibits cell proliferation upon establishing cell-cell contacts. Because Merlin has high level of sequence similarity to the Ezrin-Radixin-Moesin family of proteins, the structural model of Ezrin-Radixin-Moesin protein autoinhibition and cycling between closed/resting and open/active conformational states is often employed to explain Merlin function. However, recent biochemical studies suggest alternative molecular models of Merlin function. Here, we have det ...[more]