Ontology highlight
ABSTRACT:
SUBMITTER: Telen MJ
PROVIDER: S-EPMC4408290 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Telen Marilyn J MJ Wun Ted T McCavit Timothy L TL De Castro Laura M LM Krishnamurti Lakshmanan L Lanzkron Sophie S Hsu Lewis L LL Smith Wally R WR Rhee Seungshin S Magnani John L JL Thackray Helen H
Blood 20150302 17
Treatment of vaso-occlusive crises (VOC) or events in sickle cell disease (SCD) remains limited to symptom relief with opioids. Animal models support the effectiveness of the pan-selectin inhibitor GMI-1070 in reducing selectin-mediated cell adhesion and abrogating VOC. We studied GMI-1070 in a prospective multicenter, randomized, placebo-controlled, double-blind, phase 2 study of 76 SCD patients with VOC. Study drug (GMI-1070 or placebo) was given every 12 hours for up to 15 doses. Other treatm ...[more]