Clonal dynamics of native haematopoiesis.
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ABSTRACT:
SUBMITTER: Sun J
PROVIDER: S-EPMC4408613 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Clonal dynamics of native haematopoiesis.
Sun Jianlong J Ramos Azucena A Chapman Brad B Johnnidis Jonathan B JB Le Linda L Ho Yu-Jui YJ Klein Allon A Hofmann Oliver O Camargo Fernando D FD
Nature 20141005 7522
It is currently thought that life-long blood cell production is driven by the action of a small number of multipotent haematopoietic stem cells. Evidence supporting this view has been largely acquired through the use of functional assays involving transplantation. However, whether these mechanisms also govern native non-transplant haematopoiesis is entirely unclear. Here we have established a novel experimental model in mice where cells can be uniquely and genetically labelled in situ to address ...[more]
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