Ontology highlight
ABSTRACT:
SUBMITTER: Fullerton MD
PROVIDER: S-EPMC4409279 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Fullerton Morgan D MD Ford Rebecca J RJ McGregor Chelsea P CP LeBlond Nicholas D ND Snider Shayne A SA Stypa Stephanie A SA Day Emily A EA Lhoták Šárka Š Schertzer Jonathan D JD Austin Richard C RC Kemp Bruce E BE Steinberg Gregory R GR
Journal of lipid research 20150315 5
Atherosclerosis stems from imbalances in lipid metabolism and leads to maladaptive inflammatory responses. The AMP-activated protein kinase (Ampk) is a highly conserved serine/threonine kinase that regulates many aspects of lipid and energy metabolism, although its specific role in controlling macrophage cholesterol homeostasis remains unclear. We sought to address this question by testing the effects of direct Ampk activators in primary bone marrow-derived macrophages from Ampk β1-deficient (β1 ...[more]