Dataset Information

High Prevalence of the BIM Deletion Polymorphism in Young Female Breast Cancer in an East Asian Country.

ABSTRACT:

Background

A rapid surge of female breast cancer has been observed in young women in several East Asian countries. The BIM deletion polymorphism, which confers cell resistance to apoptosis, was recently found exclusively in East Asian people with prevalence rate of 12%. We aimed to evaluate the possible role of this genetic alteration in carcinogenesis of breast cancer in East Asians.

Method

Female healthy volunteers (n = 307), patients in one consecutive stage I-III breast cancer cohort (n = 692) and one metastatic breast cancer cohort (n = 189) were evaluated. BIM wild-type and deletion alleles were separately genotyped in genomic DNAs.

Results

Both cancer cohorts consistently showed inverse associations between the BIM deletion polymorphism and patient age (?35 y vs. 36-50 y vs. >50 y: 29% vs. 22% vs. 15%, P = 0.006 in the consecutive cohort, and 40% vs. 23% vs. 13%, P = 0.023 in the metastatic cohort). In healthy volunteers, the frequencies of the BIM deletion polymorphism were similar (13%-14%) in all age groups. Further analyses indicated that the BIM deletion polymorphism was not associated with specific clinicopathologic features, but it was associated with poor overall survival (adjusted hazard ratio 1.71) in the consecutive cohort.

Conclusions

BIM deletion polymorphism may be involved in the tumorigenesis of the early-onset breast cancer among East Asians.

SUBMITTER: Lin CH

PROVIDER: S-EPMC4409392 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

High Prevalence of the BIM Deletion Polymorphism in Young Female Breast Cancer in an East Asian Country.

Lin Ching-Hung CH Shen Chen-Yang CY Lee Jih-Hsiang JH Huang Chiun-Sheng CS Yang Chih-Hsin CH Kuo Wen-Hung WH Chang Dwan-Ying DY Hsiung Chia-Ni CN Kuo Kuan-Ting KT Chen Wei-Wu WW Chen I-Chun IC Wu Pei-Fang PF Kuo Sung-Hsin SH Chen Chien-Jen CJ Lu Yen-Shen YS Cheng Ann-Lii AL

PloS one 20150424 4

<h4>Background</h4>A rapid surge of female breast cancer has been observed in young women in several East Asian countries. The BIM deletion polymorphism, which confers cell resistance to apoptosis, was recently found exclusively in East Asian people with prevalence rate of 12%. We aimed to evaluate the possible role of this genetic alteration in carcinogenesis of breast cancer in East Asians.<h4>Method</h4>Female healthy volunteers (n = 307), patients in one consecutive stage I-III breast cancer ...[more]

PMID: 25909194

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Project description:There is increasing interest in clarifying how different face emotion expressions are perceived by people from different cultures, of different ages and sex. However, scant availability of well-controlled emotional face stimuli from non-Western populations limit the evaluation of cultural differences in face emotion perception and how this might be modulated by age and sex differences. We present a database of East Asian face expression stimuli, enacted by young and older, male and female, Taiwanese using the Facial Action Coding System (FACS). Combined with a prior database, this present database consists of 90 identities with happy, sad, angry, fearful, disgusted, surprised and neutral expressions amounting to 628 photographs. Twenty young and 24 older East Asian raters scored the photographs for intensities of multiple-dimensions of emotions and induced affect. Multivariate analyses characterized the dimensionality of perceived emotions and quantified effects of age and sex. We also applied commercial software to extract computer-based metrics of emotions in photographs. Taiwanese raters perceived happy faces as one category, sad, angry, and disgusted expressions as one category, and fearful and surprised expressions as one category. Younger females were more sensitive to face emotions than younger males. Whereas, older males showed reduced face emotion sensitivity, older female sensitivity was similar or accentuated relative to young females. Commercial software dissociated six emotions according to the FACS demonstrating that defining visual features were present. Our findings show that East Asians perceive a different dimensionality of emotions than Western-based definitions in face recognition software, regardless of age and sex. Critically, stimuli with detailed cultural norms are indispensable in interpreting neural and behavioral responses involving human facial expression processing. To this end, we add to the tools, which are available upon request, for conducting such research.

Dataset Information

High Prevalence of the BIM Deletion Polymorphism in Young Female Breast Cancer in an East Asian Country.

Background

Method

Results

Conclusions

Publications

High Prevalence of the BIM Deletion Polymorphism in Young Female Breast Cancer in an East Asian Country.

Similar Datasets

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