Ontology highlight
ABSTRACT:
SUBMITTER: Berntsen NL
PROVIDER: S-EPMC4409500 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Gastroenterology 20150202 5
Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B* ...[more]