Ontology highlight
ABSTRACT:
SUBMITTER: Giorgi EE
PROVIDER: S-EPMC4409949 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Giorgi Elena E EE Stram Daniel O DO Taverna Darin D Turner Stephen D SD Schumacher Fredrick F Haiman Christopher A CA Lum-Jones Annette A Tirikainen Maarit M Caberto Christian C Duggan David D Henderson Brian E BE Le Marchand Loic L Cheng Iona I
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20140605 9
Genetic variation at insulin-like growth factor 1 (IGF1) has been linked to prostate cancer risk. However, the specific predisposing variants have not been identified. In this study, we fine-mapped the IGF1 locus for prostate cancer risk in African Americans. We conducted targeted Roche GS-Junior 454 resequencing of a 156-kb region of IGF1 in 80 African American aggressive prostate cancer cases. Three hundred and thirty-four IGF1 SNPs were examined for their association with prostate cancer risk ...[more]