Network-based inference methods for drug repositioning.
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ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC4410541 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Network-based inference methods for drug repositioning.
Chen Hailin H Zhang Heng H Zhang Zuping Z Cao Yiqin Y Tang Wenliang W
Computational and mathematical methods in medicine 20150412
Mining potential drug-disease associations can speed up drug repositioning for pharmaceutical companies. Previous computational strategies focused on prior biological information for association inference. However, such information may not be comprehensively available and may contain errors. Different from previous research, two inference methods, ProbS and HeatS, were introduced in this paper to predict direct drug-disease associations based only on the basic network topology measure. Bipartite ...[more]
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