Ontology highlight
ABSTRACT:
SUBMITTER: Wheeler JB
PROVIDER: S-EPMC4410689 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Wheeler Jason B JB Ikonomidis John S JS Jones Jeffrey A JA
Advances in experimental medicine and biology 20140101
Marfan Syndrome (MFS) and Loeys-Dietz Syndrome (LDS) represent heritable connective tissue disorders that cosegregate with a similar pattern of cardiovascular defects (thoracic aortic aneurysm, mitral valve prolapse/regurgitation, and aortic root dilatation with regurgitation). This pattern of cardiovascular defects appears to be expressed along a spectrum of severity in many heritable connective tissue disorders and raises suspicion of a relationship between the normal development of connective ...[more]