Surfaces that sequester serum-borne heparin amplify growth factor activity.
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ABSTRACT:
SUBMITTER: Hudalla GA
PROVIDER: S-EPMC4410730 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
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Surfaces that sequester serum-borne heparin amplify growth factor activity.
Hudalla Gregory A GA Koepsel Justin T JT Murphy William L WL
Advanced materials (Deerfield Beach, Fla.) 20111026 45
Surfaces presenting a heparin-binding peptide can non-covalently sequester heparin from culture supplements, such as fetal bovine serum. In turn, sequestered, serum-borne heparin can non-covalently localize growth factors at the cell-material interface, resulting in amplified growth factor bioactivity. ...[more]
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