Notch signaling respecifies the hemangioblast to a cardiac fate.
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ABSTRACT:
SUBMITTER: Chen VC
PROVIDER: S-EPMC4410743 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Publications
Notch signaling respecifies the hemangioblast to a cardiac fate.
Chen Vincent C VC Stull Robert R Joo Daniel D Cheng Xin X Keller Gordon G
Nature biotechnology 20080928 10
To efficiently generate cardiomyocytes from embryonic stem (ES) cells in culture it is essential to identify key regulators of the cardiac lineage and to develop methods to control them. Using a tet-inducible mouse ES cell line to enforce expression of a constitutively activated form of the Notch 4 receptor, we show that signaling through the Notch pathway can efficiently respecify hemangioblasts to a cardiac fate, resulting in the generation of populations consisting of >60% cardiomyocytes. Mic ...[more]
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