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Antigenic Relatedness of Norovirus GII.4 Variants Determined by Human Challenge Sera.


ABSTRACT: The GII.4 noroviruses (NoVs) are a single genotype that is responsible for over 50% of NoV gastroenteritis epidemics worldwide. However, GII.4 NoVs have been found to undergo antigenic drifts, likely selected by host herd immunity, which raises an issue for vaccine strategies against NoVs. We previously characterized GII.4 NoV antigenic variations and found significant levels of antigenic relatedness among different GII.4 variants. Further characterization of the genetic and antigenic relatedness of recent GII.4 variants (2008b and 2010 cluster) was performed in this study. The amino acid sequences of the receptor binding interfaces were highly conserved among all GII.4 variants from the past two decades. Using serum samples from patients enrolled in a GII.4 virus challenge study, significant cross-reactivity between major GII.4 variants from 1998 to 2012 was observed using enzyme-linked immunosorbent assays and HBGA receptor blocking assays. The overall abilities of GII.4 NoVs to bind to the A/B/H HBGAs were maintained while their binding affinities to individual ABH antigens varied. These results highlight the importance of human HBGAs in NoV evolution and how conserved antigenic types impact vaccine development against GII.4 variants.

SUBMITTER: Dai YC 

PROVIDER: S-EPMC4411064 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Antigenic Relatedness of Norovirus GII.4 Variants Determined by Human Challenge Sera.

Dai Ying-Chun YC   Zhang Xu-Fu XF   Xia Ming M   Tan Ming M   Quigley Christina C   Lei Wen W   Fang Hao H   Zhong Weiming W   Lee Bonita B   Pang Xiaoli X   Nie Jun J   Jiang Xi X  

PloS one 20150427 4


The GII.4 noroviruses (NoVs) are a single genotype that is responsible for over 50% of NoV gastroenteritis epidemics worldwide. However, GII.4 NoVs have been found to undergo antigenic drifts, likely selected by host herd immunity, which raises an issue for vaccine strategies against NoVs. We previously characterized GII.4 NoV antigenic variations and found significant levels of antigenic relatedness among different GII.4 variants. Further characterization of the genetic and antigenic relatednes  ...[more]

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