Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC4411275 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Zhang Chenying C Ponugoti Bhaskar B Tian Chen C Xu Fanxing F Tarapore Rohinton R Batres Angelika A Alsadun Sarah S Lim Jason J Dong Guangyu G Graves Dana T DT
The Journal of cell biology 20150401 2
Healing is delayed in diabetic wounds. We previously demonstrated that lineage-specific Foxo1 deletion in keratinocytes interfered with normal wound healing and keratinocyte migration. Surprisingly, the same deletion of Foxo1 in diabetic wounds had the opposite effect, significantly improving the healing response. In normal glucose media, forkhead box O1 (FOXO1) enhanced keratinocyte migration through up-regulating TGFβ1. In high glucose, FOXO1 nuclear localization was induced but FOXO1 did not ...[more]