Pentameric Ligand-gated Ion Channels : Insights from Computation.
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ABSTRACT:
SUBMITTER: Salari R
PROVIDER: S-EPMC4412168 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Pentameric Ligand-gated Ion Channels : Insights from Computation.
Salari Reza R Murlidaran Sruthi S Brannigan Grace G
Molecular simulation 20140401 10-11
Pentameric ligand-gated ion channels (pLGICs) conduct upon the binding of an agonist and are fundamental to neurotransmission. New insights into the complex mechanisms underlying pLGIC gating, ion selectivity, and modulation have recently been gained via a series of crystal structures in prokaryotes and <i>C .elegans</i>, as well as computational studies relying on these structures. Here we review contributions from a variety of computational approaches, including normal mode analysis, automated ...[more]
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