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Comparative sequence analyses of La Crosse virus strain isolated from patient with fatal encephalitis, Tennessee, USA.

ABSTRACT: We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child's home just after his postmortem diagnosis. In addition, we conducted phylogenetic analyses of these and other sequences derived from LACV strains representing varied temporal, geographic, and ecologic origins. Consistent with historical findings, results of these analyses indicate that a limited range of LACV lineage I genotypes is associated with severe clinical outcomes.

SUBMITTER: Lambert AJ

PROVIDER: S-EPMC4412244 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Comparative sequence analyses of La Crosse virus strain isolated from patient with fatal encephalitis, Tennessee, USA.

Lambert Amy J AJ Fryxell Rebecca Trout RT Freyman Kimberly K Ulloa Armando A Velez Jason O JO Paulsen Dave D Lanciotti Robert S RS Moncayo Abelardo A

Emerging infectious diseases 20150501 5

We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child's home just after his postmortem diagnosis. In addition, we conducted phylogenetic analyses of these and other sequences derived from LACV strains representing varied temporal, geographic, and ecologic origins. Consistent with historical find ...[more]

PMID: 25898269

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