Ontology highlight
ABSTRACT:
SUBMITTER: Shimokawa-Chiba N
PROVIDER: S-EPMC4413333 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Shimokawa-Chiba Naomi N Kumazaki Kaoru K Tsukazaki Tomoya T Nureki Osamu O Ito Koreaki K Chiba Shinobu S
Proceedings of the National Academy of Sciences of the United States of America 20150408 16
The recently solved crystal structure of YidC protein suggests that it mediates membrane protein insertion by means of an intramembrane cavity rather than a transmembrane (TM) pore. This concept of protein translocation prompted us to characterize the native, membrane-integrated state of YidC with respect to the hydropathic nature of its TM region. Here, we show that the cavity-forming region of the stage III sporulation protein J (SpoIIIJ), a YidC homolog, is indeed open to the aqueous milieu o ...[more]