Ontology highlight
ABSTRACT:
SUBMITTER: Xiao X
PROVIDER: S-EPMC4413649 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Xiao Xiao X Liu Zhiguo Z Wang Rui R Wang Jiayin J Zhang Song S Cai Xiqiang X Wu Kaichun K Bergan Raymond C RC Xu Li L Fan Daiming D
Oncotarget 20150201 5
Dietary consumption of genistein, found in soy, has been associated with a potentially protective role in colorectal cancer (CRC) development and progression. Herein we demonstrate that genistein will inhibit human CRC cell invasion and migration, that it does so at non-cytotoxic concentrations and we demonstrate this in multiple human CRC cell lines. After orthotopic implantation of human CRC tumors into mice, oral genistein did not inhibit tumor growth, but did inhibit distant metastasis forma ...[more]