Ontology highlight
ABSTRACT:
SUBMITTER: Dimke H
PROVIDER: S-EPMC4413754 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Dimke Henrik H Sparks Matthew A MA Thomson Benjamin R BR Frische Sebastian S Coffman Thomas M TM Quaggin Susan E SE
Journal of the American Society of Nephrology : JASN 20141110 5
Vascular endothelial growth factor A (VEGFA) production by podocytes is critical for glomerular endothelial health. VEGFA is also expressed in tubular epithelial cells in kidney; however, its physiologic role in the tubule has not been established. Using targeted transgenic mouse models, we found that Vegfa is expressed by specific epithelial cells along the nephron, whereas expression of its receptor (Kdr/Vegfr2) is largely restricted to adjacent peritubular capillaries. Embryonic deletion of t ...[more]