Ontology highlight
ABSTRACT:
SUBMITTER: Lee G
PROVIDER: S-EPMC4414087 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Lee Gina G Liang Chengyu C Park Gihyun G Jang Cholsoon C Jung Jae U JU Chung Jongkyeong J
Developmental biology 20110625 2
Heterotaxy characterized by abnormal left-right body asymmetry causes diverse congenital anomalies. Organ rotation is a crucial developmental process to establish the left-right patterning during animal development. However, the molecular basis of how organ rotation is regulated is poorly understood. Here we report that Drosophila UV-resistance associated gene (UVRAG), a tumor suppressor that regulates autophagy and endocytosis, plays unexpected roles in controlling organ rotation. Loss-of-funct ...[more]