The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3.
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ABSTRACT:
SUBMITTER: Sechi S
PROVIDER: S-EPMC4414131 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3.
Sechi Stefano S Frappaolo Anna A Belloni Giorgio G Colotti Gianni G Giansanti Maria Grazia MG
Oncotarget 20150201 6
The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein, a component of Trans-Golgi Network (TGN), has been defined as a "first-in-class Golgi oncoprotein" and characterized as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is commonly amplified in several solid tumors. Furthermore this protein has been associated with poor prognosis in many cancers. Highly conserved from yeast to humans, GOLPH3 provides an essential function in vesicle trafficking and Golgi struc ...[more]
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