Ontology highlight
ABSTRACT:
SUBMITTER: McKee CM
PROVIDER: S-EPMC4414153 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
McKee Chad M CM Ding Yunchuan Y Zhou Jianfeng J Li Chunrui C Huang Liang L Xin Xiangke X He Jing J Allen Joshua E JE El-Deiry Wafik S WS Cao Yunhong Y Muschel Ruth J RJ Xu Danmei D
Oncotarget 20150201 6
Protease nexin 1 (PN1) is an endogenous serine protease inhibitor (SERPIN), expressed at high levels in the prostate, and capable of inhibiting the proliferation of prostate cancer cells. We previously showed that PN1-uPA complexes inhibited Sonic Hedgehog (SHH) signalling through engagement of the LRP receptor. Here, we describe an alternative anti-proliferative mechanism through which PN1 expression leads to apoptosis. In prostate cancer cells, increased expression of PN1 led to substantial re ...[more]