Ontology highlight
ABSTRACT:
SUBMITTER: Cai S
PROVIDER: S-EPMC4414162 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cai Songwang S Chen Ruihan R Li Xiaojuan X Cai Yi Y Ye Zhiqiang Z Li Shigeng S Li Jun J Huang Huaiqiu H Peng Shubin S Wang Jun J Tao Yiran Y Huang Hongxing H Wen Xinglai X Mo Jianfeng J Deng Zhupeng Z Wang Jian J Zhang Yangfan Y Gao Xin X Wen Xingqiao X
Oncotarget 20150201 6
Here we found that levels of miR-23a were decreased in prostate cancer cell lines and tumor tissues. These low levels were associated with poor patients' prognosis. MiR-23a inhibited migration and invasion of prostate cancer in vivo and in orthotopic prostate cancer mice model. MiR-23a decreased levels of p21-activated kinase 6 (PAK6). Expression of miR-23a inhibited phosphorylation of LIM kinase 1 (LIMK1) and cofilin, in turn suppressing formation of stress fibers and actin filaments, which was ...[more]