MiR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBP?.
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ABSTRACT:
SUBMITTER: Zhang XF
PROVIDER: S-EPMC4414178 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPβ.
Zhang Xiao-Fei XF Li Ke-ke KK Gao Lu L Li Shang-Ze SZ Chen Ke K Zhang Jun-Bin JB Wang Di D Tu Rong-Fu RF Zhang Jin-Xiang JX Tao Kai-Xiong KX Wang Guobin G Zhang Xiao-Dong XD
Oncotarget 20150201 6
MicroRNA-191 (miR-191), a small non-coding RNA, is involved in disease development and cancer diagnosis and prognosis. However, how miR-191 functions in colorectal cancer remains largely unclear. In this study, we show that miR-191 is highly expressed in colon tumor tissues, and that inhibition of miR-191 leads to decreased cell growth, proliferation and tumorigenicity in a xenograft model. Overexpression of miR-191 in colorectal cancer cell lines alters cell cycle progression and cell resistanc ...[more]
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