Skeletal muscle fat content is inversely associated with bone strength in young girls.

ABSTRACT: Childhood obesity is an established risk factor for metabolic disease. The influence of obesity on bone development, however, remains controversial and may depend on the pattern of regional fat deposition. Therefore, we examined the associations of regional fat compartments of the calf and thigh with weight-bearing bone parameters in girls. Data from 444 girls aged 9 to 12 years from the Jump-In: Building Better Bones study were analyzed. Peripheral quantitative computed tomography (pQCT) was used to assess bone parameters at metaphyseal and diaphyseal sites of the femur and tibia along with subcutaneous adipose tissue (SAT, mm(2) ) and muscle density (mg/cm(3) ), an index of skeletal muscle fat content. As expected, SAT was positively correlated with total-body fat mass (r?=?0.87-0.89, p??.05), except the distal tibia (??=?0.09, p?=?.03). In conclusion, skeletal muscle fat content of the calf and thigh is inversely associated with weight-bearing bone strength in young girls.

SUBMITTER: Farr JN 

PROVIDER: S-EPMC4414314 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature