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Ambulatory hypertension subtypes and 24-hour systolic and diastolic blood pressure as distinct outcome predictors in 8341 untreated people recruited from 12 populations.


ABSTRACT: Data on risk associated with 24-hour ambulatory diastolic (DBP24) versus systolic (SBP24) blood pressure are scarce.We recorded 24-hour blood pressure and health outcomes in 8341 untreated people (mean age, 50.8 years; 46.6% women) randomly recruited from 12 populations. We computed hazard ratios (HRs) using multivariable-adjusted Cox regression. Over 11.2 years (median), 927 (11.1%) participants died, 356 (4.3%) from cardiovascular causes, and 744 (8.9%) experienced a fatal or nonfatal cardiovascular event. Isolated diastolic hypertension (DBP24?80 mm?Hg) did not increase the risk of total mortality, cardiovascular mortality, or stroke (HRs?1.54; P?0.18), but was associated with a higher risk of fatal combined with nonfatal cardiovascular, cardiac, or coronary events (HRs?1.75; P?0.0054). Isolated systolic hypertension (SBP24?130 mm?Hg) and mixed diastolic plus systolic hypertension were associated with increased risks of all aforementioned end points (P?0.0012). Below age 50, DBP24 was the main driver of risk, reaching significance for total (HR for 1-SD increase, 2.05; P=0.0039) and cardiovascular mortality (HR, 4.07; P=0.0032) and for all cardiovascular end points combined (HR, 1.74; P=0.039) with a nonsignificant contribution of SBP24 (HR?0.92; P?0.068); above age 50, SBP24 predicted all end points (HR?1.19; P?0.0002) with a nonsignificant contribution of DBP24 (0.96?HR?1.14; P?0.10). The interactions of age with SBP24 and DBP24 were significant for all cardiovascular and coronary events (P?0.043).The risks conferred by DBP24 and SBP24 are age dependent. DBP24 and isolated diastolic hypertension drive coronary complications below age 50, whereas above age 50 SBP24 and isolated systolic and mixed hypertension are the predominant risk factors.

SUBMITTER: Li Y 

PROVIDER: S-EPMC4414316 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Ambulatory hypertension subtypes and 24-hour systolic and diastolic blood pressure as distinct outcome predictors in 8341 untreated people recruited from 12 populations.

Li Yan Y   Wei Fang-Fei FF   Thijs Lutgarde L   Boggia José J   Asayama Kei K   Hansen Tine W TW   Kikuya Masahiro M   Björklund-Bodegård Kristina K   Ohkubo Takayoshi T   Jeppesen Jørgen J   Gu Yu-Mei YM   Torp-Pedersen Christian C   Dolan Eamon E   Liu Yan-Ping YP   Kuznetsova Tatiana T   Stolarz-Skrzypek Katarzyna K   Tikhonoff Valérie V   Malyutina Sofia S   Casiglia Edoardo E   Nikitin Yuri Y   Lind Lars L   Sandoya Edgardo E   Kawecka-Jaszcz Kalina K   Mena Luis L   Maestre Gladys E GE   Filipovský Jan J   Imai Yutaka Y   O'Brien Eoin E   Wang Ji-Guang JG   Staessen Jan A JA  

Circulation 20140606 6


<h4>Background</h4>Data on risk associated with 24-hour ambulatory diastolic (DBP24) versus systolic (SBP24) blood pressure are scarce.<h4>Methods and results</h4>We recorded 24-hour blood pressure and health outcomes in 8341 untreated people (mean age, 50.8 years; 46.6% women) randomly recruited from 12 populations. We computed hazard ratios (HRs) using multivariable-adjusted Cox regression. Over 11.2 years (median), 927 (11.1%) participants died, 356 (4.3%) from cardiovascular causes, and 744  ...[more]

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