Ontology highlight
ABSTRACT:
SUBMITTER: Topolska-Wos AM
PROVIDER: S-EPMC4415008 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Topolska-Woś Agnieszka M AM Shell Steven M SM Kilańczyk Ewa E Szczepanowski Roman H RH Chazin Walter J WJ Filipek Anna A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20150121 5
CacyBP/SIP [calcyclin-binding protein/Siah-1 [seven in absentia homolog 1 (Siah E3 ubiquitin protein ligase 1)] interacting protein] is a multifunctional protein whose activity includes acting as an ERK1/2 phosphatase. We analyzed dimerization of mouse CacyBP/SIP in vitro and in mouse neuroblastoma cell line (NB2a) cells, as well as the structure of a full-length protein. Moreover, we searched for the CacyBP/SIP domain important for dimerization and dephosphorylation of ERK2, and we analyzed the ...[more]