Ontology highlight
ABSTRACT:
SUBMITTER: Taverna Porro ML
PROVIDER: S-EPMC4415041 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Taverna Porro Marisa L ML Greenberg Marc M MM
Chemical research in toxicology 20150309 4
Double-strand breaks are widely accepted to be the most toxic form of DNA damage. Molecules that produce double-strand breaks via a single chemical event are typically very cytotoxic and far less common than those that form single-strand breaks. It was recently reported that a commonly formed C4'-radical produces double-strand breaks under aerobic conditions. Experiments described herein indicate that a peroxyl radical initiates strand damage on the complementary strand via C4'-hydrogen atom abs ...[more]