Ontology highlight
ABSTRACT:
SUBMITTER: Jiang W
PROVIDER: S-EPMC4415111 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Jiang Wenxia W Crowe Jennifer L JL Liu Xiangyu X Nakajima Satoshi S Wang Yunyue Y Li Chen C Lee Brian J BJ Dubois Richard L RL Liu Chao C Yu Xiaochun X Lan Li L Zha Shan S
Molecular cell 20150326 1
Nonhomologous end-joining (NHEJ) is a major DNA double-strand break repair pathway that is conserved in eukaryotes. In vertebrates, NHEJ further acquires end-processing capacities (e.g., hairpin opening) in addition to direct end-ligation. The catalytic subunit of DNA-PK (DNA-PKcs) is a vertebrate-specific NHEJ factor that can be autophosphorylated or transphosphorylated by ATM kinase. Using a mouse model expressing a kinase-dead (KD) DNA-PKcs protein, we show that ATM-mediated transphosphorylat ...[more]