Cellular hallmarks reveal restricted aerobic metabolism at thermal limits.
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ABSTRACT:
SUBMITTER: Neves A
PROVIDER: S-EPMC4415524 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
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Cellular hallmarks reveal restricted aerobic metabolism at thermal limits.
Neves Aitana A Busso Coralie C Gönczy Pierre P
eLife 20150501
All organisms live within a given thermal range, but little is known about the mechanisms setting the limits of this range. We uncovered cellular features exhibiting signature changes at thermal limits in Caenorhabditis elegans embryos. These included changes in embryo size and shape, which were also observed in Caenorhabditis briggsae, indicating evolutionary conservation. We hypothesized that such changes could reflect restricted aerobic capacity at thermal limits. Accordingly, we uncovered th ...[more]
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