Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population.
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SUBMITTER: Kurzawski M
PROVIDER: S-EPMC4415567 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
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Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population.
Kurzawski Mateusz M Wajda Anna A Malinowski Damian D Kazienko Anna A Kurzawa Rafal R Drozdzik Marek M
Genetics and molecular biology 20140317 1
Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms in a Polish population. No significant differences in genotype or allele frequencies were detected between the groups of 284 infertile men and of 352 fertile controls. These results demonstrat ...[more]
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