Ontology highlight
ABSTRACT:
SUBMITTER: Ejarque-Ortiz A
PROVIDER: S-EPMC4415817 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ejarque-Ortiz Aroa A Solà Carme C Martínez-Barriocanal Águeda Á Schwartz Simó S Martín Margarita M Peluffo Hugo H Sayós Joan J
PloS one 20150430 4
CMRF35-like molecule-1 (CLM-1) belongs to a receptor family mainly expressed in myeloid cells that include activating and inhibitory receptors. CLM-1 contains two ITIMs and a single immunoreceptor tyrosine-based switch motif (ITSM), although also displays a binding site for p85α regulatory subunit of PI3K. By using murine primary microglial cultures, we show the presence of all CLM members in microglial cells and characterize the expression of CLM-1 both in basal conditions and during microglial ...[more]