Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma.
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ABSTRACT:
SUBMITTER: Boesaard EP
PROVIDER: S-EPMC4416291 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma.
Boesaard Ewout P EP Vogelaar Ingrid P IP Bult Peter P Wauters Carla Ap CA van Krieken J Han Jm JH Ligtenberg Marjolijn Jl MJ van der Post Rachel S RS Hoogerbrugge Nicoline N
Hereditary cancer in clinical practice 20141212 1
MUTYH-associated polyposis (MAP) is an autosomal recessive disease, which predisposes to polyposis and colorectal cancer. There is a trend towards an increased risk of breast cancer in MAP patients, with a remarkable proportion of papillary breast cancers. To determine whether MUTYH mutations are associated with this specific and rare type of breast cancer, 53 unselected patients with papillary breast cancer were analyzed for founder mutations in the MUTYH gene. No germline mutations were identi ...[more]
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