Ontology highlight
ABSTRACT:
SUBMITTER: Bi J
PROVIDER: S-EPMC4416434 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Bi Jingjing J Wang Jing J Zhou Kai K Wang Yuancheng Y Fang Min M Du Yuguo Y
ACS medicinal chemistry letters 20150211 4
NKT cells, a unique subset of T cells that recognizes glycolipid antigens presented by CD1d molecules, are believed to produce key cytokines of both Th1 and Th2 T cells and are thus involved in the control of several types of immune response. As an active glycolipid antigen having α-galactosyl ceramide core structure, KRN7000 showed promising immunostimulation activity and was selected as an anticancer drug candidate for further clinical application. In this report, three new KRN7000 structural ...[more]