Ontology highlight
ABSTRACT:
SUBMITTER: Kardos GR
PROVIDER: S-EPMC4416652 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Pigment cell & melanoma research 20140616 5
Ribosome biogenesis can modulate protein synthesis, a process heavily relied upon for cancer cell proliferation. In this study, involvement of large subunit ribosomal proteins (RPLs) in melanoma has been dissected and RPLs categorized based on modulation of cell proliferation and therapeutic targeting potential. Based on these results, two categories of RPLs were identified: the first causing negligible effects on cell viability, p53 expression, and protein translation, while the second category ...[more]