Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes.
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ABSTRACT:
SUBMITTER: Lee CY
PROVIDER: S-EPMC4417006 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes.
Lee Chih-Ying CY Horn Henning F HF Stewart Colin L CL Burke Brian B Bolcun-Filas Ewelina E Schimenti John C JC Dresser Michael E ME Pezza Roberto J RJ
Cell reports 20150416 4
Telomere-led rapid prophase movements (RPMs) in meiotic prophase have been observed in diverse eukaryote species. A shared feature of RPMs is that the force that drives the chromosomal movements is transmitted from the cytoskeleton, through the nuclear envelope, to the telomeres. Studies in mice suggested that dynein movement along microtubules is transmitted to telomeres through SUN1/KASH5 nuclear envelope bridges to generate RPMs. We monitored RPMs in mouse seminiferous tubules using 4D fluore ...[more]
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