Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Berna AJ
PROVIDER: S-EPMC4417152 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Pérez-Berná Ana J AJ Marion Sanjin S Chichón F Javier FJ Fernández José J JJ Winkler Dennis C DC Carrascosa José L JL Steven Alasdair C AC Šiber Antonio A San Martín Carmen C
Nucleic acids research 20150327 8
Genome packing in adenovirus has long evaded precise description, since the viral dsDNA molecule condensed by proteins (core) lacks icosahedral order characteristic of the virus protein coating (capsid). We show that useful insights regarding the organization of the core can be inferred from the analysis of spatial distributions of the DNA and condensing protein units (adenosomes). These were obtained from the inspection of cryo-electron tomography reconstructions of individual human adenovirus ...[more]