Ontology highlight
ABSTRACT:
SUBMITTER: Rossetti G
PROVIDER: S-EPMC4417165 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Nucleic acids research 20150327 8
The structure and dynamics of all the transversion and transition mismatches in three different DNA environments have been characterized by molecular dynamics simulations and NMR spectroscopy. We found that the presence of mismatches produced significant local structural alterations, especially in the case of purine transversions. Mismatched pairs often show promiscuous hydrogen bonding patterns, which interchange among each other in the nanosecond time scale. This therefore defines flexible bas ...[more]